Our paper indicates DNA demethylation of the autoregulatory region of TDP-43 interferes with the TDP-43 autoregulation resulting in increasing TDP-43. The DNA demethylation increases in the human motor cortex by age. The tissue-specific, age-dependent demethylation may underlie the nature of ALS.
Contact tracing has the benefit of only affecting those that are at a higher risk of infection. However, it hasn't worked well in the UK. In this modelling study we examined why contract tracing has been ineffective and found that the populations adherence to the scheme is the most important factor.
RNA binding proteins play multiple roles in RNA metabolism, and their mutation, delocalization and/or altered expression have been proposed to cause amyotrophic lateral sclerosis. Elucidating the underlying molecular mechanisms is of crucial importance to design therapeutic approaches.
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