Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Early anesthesia using ketamine may affect addictive behavior later in life
Although anesthesia-induced neurotoxicity has received significant research interest, it is important to note that it was first identified in animals without direct clinical evidence, making it difficult to speculate how this might manifest in children.
Multi-center validation of machine learning model for preoperative prediction of postoperative mortality
This study aimed to create a machine-learning prediction model for 30-day mortality after a non-cardiac surgery that adapts to the manageable amount of clinical information as input features and is validated against multi-centered rather than single-centered data.
Hyperphosphorylated tau polymerizes into amorphous cytotoxic aggregates
One pathological hallmark of Alzheimer’s disease is the accumulation of neurofibrillary tangles that are primarily consisted of hyperphosphorylated tau. Our results highlighted the impact of hyperphosphorylation on tau leading to the spontaneous formation of amorphous cytotoxic aggregates.
The SARS-CoV-2 Omicron variant is associated with less severe disease in a high-risk cohort of Veterans
Globally, reports have shown that the COVID-19 Omicron variant results in less severe disease compared to previous variants, including Delta. The extent to which disease severity differs based on vaccination status and in high-risk populations is poorly characterized.
Behind the ALS - How does the protein SOD1 convert between physiological and pathological states?
ALS is a famous neurodegenerative disease. Misfolded SOD1 has been linked to both familial and sporadic ALS. Here, we present a cryo-EM structure of SOD1 fibrils, providing insights into the conversion of SOD1 from its immature form into an aggregated form during pathogenesis of ALS.
Establishing semantic interoperability across cohorts at European level
A prompt response to a pandemic requires data from different sources to be merged and analyzed in the most efficient way. Our work describes how we approached this challenge for COVID-19 data within the European Project ORCHESTRA
Metabolic (dysfunction) associated fatty liver disease in normal weight individuals
There has previously been no rigorous attempt to understand the pathophysiology of MAFLD in healthy weight individuals. This was the aim of our review
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Metabolism across species: using transcriptome profiling to investigate glycolytic and oxidative flux in mammalian embryos
Mammalian embryology research relies on animal models with different developmental timelines and implantation modes. Here, we present a cross-species analysis of 15 single-cell RNA-seq datasets showing conserved glycolysis and oxidative phosphorylation trends in pre-gastrulation mammalian embryos.
