Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Newly defined biomarker may accelerate clinical trials for vaccines to prevent HIV-1 infection – the Antibody Mediated Prevention (AMP) trials
A new biomarker appears to be an effective surrogate endpoint to reliably predict the ability of broadly neutralizing monoclonal antibodies to prevent acquisition of HIV-1. Broadly neutralizing antibodies (bnAbs) are defined by their ability to neutralize multiple genetically distinct viral strains.
Retrospective detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium
Multiple non-endemic countries were recently hit by a monkeypox virus outbreak. While most cases present with lesions in the anogenital region, it is unclear whether asymptomatic or otherwise undiagnosed infections are fuelling this epidemic.
Huntingtin’s new interaction site: a tale of DNAJB1 and HTT’s proline-rich domain
by Sara Maria Ayala Mariscal, Josh Vermaas & Janine Kirstein
Cross-species experiments reveal that a less-recognized form of hearing loss may be widespread
Sensory cells in the inner ear interconvert sound vibrations and electrical signals, and neural connections carry the electrical signals to the brain. Hearing loss is thought of as damage to the sensory cells, but our results suggest that damage to neural connections may be more widespread.
Intrinsic suppression of lung innate lymphoid cells by RNA-binding protein, RBM3, through CysLTR1
Cytokine production from lung innate lymphoid cells plays a critical role in inflammatory diseases; however, little is known about how RBPs regulate ILC function. In this paper, we demonstrate the cell-intrinsic effect of RBM3 in dampening the production of type 2 and 17 cytokines in lung ILCs.
A consensus statement for digital surgery
The term ‘digital surgery’ has been widely adopted, though its meaning has not yet been defined. In this study, a panel of 38 global experts within the field of digital surgery reach consensus definition on the term ‘digital surgery’ and define key issues, barriers and future research goals.
