Restricting calorie intake extend lifespan and healthspan of many species, but the mechanism of how calorie restriction functions remains unclear. We show that prolonged fasting between meals imposed by such regimens may play a critical role in the benefits of reduced calorie diets.
Puncture wounds and how platelet leads to bleeding cessation is not normally thought of as problem in cell and developmental biology. Here a team trained in physics and biochemistry take exactly that approach to thrombus structure and how that leads to bleeding cessation in ta jugular wound.
As the COVID-19 pandemic continues there is an ever-present risk of more variants of concern (VOCs) arising. These VOCs may have beneficial mutations aiding their spread. We used three mathematical models to examine the potential drivers of SARS-CoV-2 VOC epidemics in England.
Our paper indicates DNA demethylation of the autoregulatory region of TDP-43 interferes with the TDP-43 autoregulation resulting in increasing TDP-43. The DNA demethylation increases in the human motor cortex by age. The tissue-specific, age-dependent demethylation may underlie the nature of ALS.
Contact tracing has the benefit of only affecting those that are at a higher risk of infection. However, it hasn't worked well in the UK. In this modelling study we examined why contract tracing has been ineffective and found that the populations adherence to the scheme is the most important factor.
RNA binding proteins play multiple roles in RNA metabolism, and their mutation, delocalization and/or altered expression have been proposed to cause amyotrophic lateral sclerosis. Elucidating the underlying molecular mechanisms is of crucial importance to design therapeutic approaches.
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