Advancements of studies with model organisms that cellular senescence drives ageing and age-related pathologies have elicited widespread efforts to identify compounds of a potential to selectively kill senescent cells, now termed as 'senolytics'.
We performed a GWAS for lung function with adjustment for exhaled nitric oxide (FeNO) levels to account for type 2 airway inflammation. Our study identified the genetic locus most strongly associated with airway obstruction in the Japanese population and new genetic loci associated with FeNO.
In a recent clinical trial, patients who had chronic spontaneous urticaria (CSU) for more than 6 months that would not respond to high doses of standard treatment (H1-antihistamines) – were enrolled to evaluate a “BTK blocker” drug, called, "fenebrutinib".
Normal-weight obesity is defined by the presence of normal weight according to the BMI, together with excess body fat. Although it is well recognized in the literature about the complications associated with BMI-defined obesity, few studies have evaluated normal-weight obesity in adolescents.
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