Leukemia
This journal publishes high quality, peer reviewed research that covers all aspects of the research and treatment of leukemia and allied diseases. Topics of interest include oncogenes, growth factors, stem cells, leukemia genomics, cell cycle, signal transduction and molecular targets for therapy.
Redefining high risk multiple myeloma with an APOBEC/Inflammation-based classifier.
Multiple myeloma (MM), a malignancy of plasma cells in the bone marrow, remains a significant clinical challenge due to its diverse presentation and progression.
A call for individual risk stratification on early morbidity and mortality in patients with newly diagnosed multiple myeloma
Behind the paper of „Predictors of early morbidity and mortality in newly diagnosed multiple myeloma: data from five randomized, controlled, phase III trials in 3700 patients” - an international team effort from the HOVON, EMN and GMMG study groups.
Emerging maturation stage-associated markers predict AML subtype vulnerability to cardiac glycosides: a step towards their repurposing?
A new marker associated with AML maturation predicts the AML blast response to cardiac glycosides, a class of agents used for treating arrhythmia but still waiting for a repurposing opportunity in cancer, and identifies approved regimens that would benefit from the addition of these drugs.
Secondary versus de novo ontogeny for AML in the era of molecular genetics
AML has long been classified and prognosticated based on ontogeny, that is, whether it is de novo or secondary. But several reports have suggested that disease genetics drive these outcomes as opposed to ontogeny. Here, we examine this relationship in greater detail.
Identification of leukemia-initiating cells by transcriptome profiling in a mouse model
Transcriptome profiling and identification of leukemia-initiating cells in a mouse model expressing the fusion gene CBFB-MYH11, which results from chromosome 16 inversion, a common chromosome abnormality in human acute myeloid leukemia.
Culture-associated DNA hypermethylation of CAR T cells negatively affects therapeutic outcome
Analyzing effects of vitro expansion on the methylome of chimeric antigen receptor (CAR) T cells revealed loci with increased methylation that were also associated with reduced long-term survival in patients. These findings suggest that reduced cultivation periods may benefit clinical outcome.
