An open access journal from Nature Portfolio publishing high-quality research, reviews and commentary in all areas of the biological sciences, representing significant advances and bringing new biological insight to a specialized area of research.
Pancreas or islet transplantation have been performed with the goal of curing diabetes mellitus. Recently, gene therapy and regenerative medicine using iPS or ES cells have also been newly proposed. However, these therapies are not sufficient for more than 500 million patients in the world 1.
Single-cell analysis of two heart failure mouse models leads us to investigate the role of exosomes during pathological hypertrophic remodeling.
Genome-wide association study of varicose veins identifies a protective missense variant in GJD3 enriched in the Finnish population
How amygdala plays in obsessive-compulsive disorder: Magnetic resonance imaging reveals a specific role of amygdala subregions
Accumulating evidence show amygdala involved in obsessive-compulsive disorder(OCD). Prior studies typically examined the amygdala as a homogeneous structure. Here we segment the amygdala with connectivity-based parcellation approach and suggest disorganized amygdala subregional networks in OCD.
A new study reveals essential role of ADAMTSL3, an extracellular protein of unknown function, in maintaining cardiac structure and function in the failing heart. By regulating a central heart failure signalling pathway, ADAMTSL3 emerges as a potential therapeutic target for this deadly syndrome.