Cellular & Molecular Immunology
A monthly journal from the Chinese Society of Immunology and the University of Science and Technology of China, covering both basic immunology research and clinical applications.
We sought to understand the molecular basis underlying the metabolic flexibility of activated CD8+ T cells, with particular focus on the Cap-Binding Complex adaptor protein ARS2. In doing so, we uncovered a novel link between CD28 costimulation, ARS2, alternative splicing, and anti-tumor immunity.
“A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells”.
In this paper published in Cellullar & Molecular Immunology by Martín-Cruz L/Viñuela M et al (doi:10.1038/s41423-023-01096-6), we uncover novel molecular mechanisms by which heparan sulfate-related structures associated with tumor cells promote the generation of functional Tregs in cancer.
A subpopulation of CD146+ tumor-associated macrophage
A subpopulation of CD146+ tumor-associated macrophage enhances the anti-tumor activity.
The epidermal immune microenvironment plays a dominant role in psoriasis development, as revealed by mass cytometry
Behind Paper:
The epidermal CD1c+CD11b+ cDC2s poised in the psoriasis perilesional skin, prepare the tissue and initiate inflammation,co-work with CD207+CD11chi LCs and CD5+ T cells in the psoriatic epidermis.