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Globally, reports have shown that the COVID-19 Omicron variant results in less severe disease compared to previous variants, including Delta. The extent to which disease severity differs based on vaccination status and in high-risk populations is poorly characterized.
Behind the ALS - How does the protein SOD1 convert between physiological and pathological states?
ALS is a famous neurodegenerative disease. Misfolded SOD1 has been linked to both familial and sporadic ALS. Here, we present a cryo-EM structure of SOD1 fibrils, providing insights into the conversion of SOD1 from its immature form into an aggregated form during pathogenesis of ALS.
Establishing semantic interoperability across cohorts at European level
A prompt response to a pandemic requires data from different sources to be merged and analyzed in the most efficient way. Our work describes how we approached this challenge for COVID-19 data within the European Project ORCHESTRA
Eugenia Rinaldi and 1 other
Jun 17, 2022
Metabolic (dysfunction) associated fatty liver disease in normal weight individuals
There has previously been no rigorous attempt to understand the pathophysiology of MAFLD in healthy weight individuals. This was the aim of our review
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Jun 17, 2022
Metabolism across species: using transcriptome profiling to investigate glycolytic and oxidative flux in mammalian embryos
Mammalian embryology research relies on animal models with different developmental timelines and implantation modes. Here, we present a cross-species analysis of 15 single-cell RNA-seq datasets showing conserved glycolysis and oxidative phosphorylation trends in pre-gastrulation mammalian embryos.
Jun 16, 2022
Healthy Ageing: a virtual conference by Wellcome Connecting Science
An overview of the Wellcome Connecting Science Healthy Ageing Virtual Conference (25–27 May, 2022)
Jun 15, 2022
Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows.
The SARS-CoV-2 Omicron variant is associated with less severe disease in a high-risk cohort of Veterans
Globally, reports have shown that the COVID-19 Omicron variant results in less severe disease compared to previous variants, including Delta. The extent to which disease severity differs based on vaccination status and in high-risk populations is poorly characterized.
Alexander Castro and 1 other
Jun 30, 2022
Everyone heard Omicron was less severe, but did not look at the qualifiers
Everyone wants a straightforward answer to what this pandemic means for them, and at some point, we must realize that something that is not visual that killed nearly 1,000,000 people nationally will never be straightforward.
Jan 19, 2022
Global health: what are we talking about?
Amandine Fillol and 1 other
Jan 18, 2022
On the Road
Updates from conferences, field work, lab visits, and vacations around the world.
Healthy Ageing: a virtual conference by Wellcome Connecting Science
An overview of the Wellcome Connecting Science Healthy Ageing Virtual Conference (25–27 May, 2022)
Jun 15, 2022